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Journal of Obstrectic Anaesthesia and Critical Care
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Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 108-111

Anesthetic management of parturient with hyperhomocysteinemia for cesarean section

Department of Anesthesiology and Critical Care, Jaipur Golden Hospital, New Delhi, India

Correspondence Address:
Dr. Radha Gupta
Department of Anesthesiology and Critical Care, Jaipur Golden Hospital, Rohini, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joacc.JOACC_44_17

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Hyperhomocysteinemia is due to genetic and acquired changes in the metabolism of homocysteine. It is associated with an increased risk for vascular occlusive disease and thrombosis. Because methylene tetrahydrofolate reductase abnormality is a genetic disorder and hyperhomocysteinemia along with pregnancy in women further aggravates the risk of thrombosis; therefore, these patients undergo antepartum anticoagulant treatment with low molecular weight heparin. These patients pose a unique challenge to anesthetist, when it comes to choosing a type of anesthesia. Neuraxial anesthesia techniques may be relatively contraindicated in anticoagulated patients and nitrous oxide may exacerbate the condition, by inhibiting the conversion of homocysteine to methionine. In this study, we intend to discuss the anesthetic implications and management of a pregnant patient with hyperhomocysteinemia undergoing cesarean section.

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