Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Journal of Obstrectic Anaesthesia and Critical Care
Search articles
Home Print this page Email this page Small font size Default font size Increase font size Users Online: 530
ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 2  |  Page : 94-98

Effect of intravenous ondansetron on maternal hemodynamics during elective caesarean section under subarachnoid block


1 Department of Anaesthesia, Max Hospital, Mohali, Punjab, India
2 Department of Anaesthesia, DMCH, Ludhiana , Punjab, India
3 Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India

Correspondence Address:
Dr. Namrata Sharma
Department of Anaesthesia (1st Floor), DMCH, Ludhiana - 141 001, Punjab
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joacc.JOACC_27_19

Rights and Permissions

Background and Aims: The Bezold–Jarisch reflex (BJR) is considered to contribute to subarachnoid block (SAB)-induced hypotension and bradycardia and is mediated by serotonin receptors (5-HT3 subtype). Ondansetron, a 5-HT3 receptor antagonist, is assumed to block the effect of serotonin and inhibit BJR. The aim was to study the effect of intravenous ondansetron on maternal hemodynamics. Materials and Methods: The study was conducted on 150 healthy parturients scheduled for elective caesarean section under SAB who were randomly allocated into two groups of 75 each to receive either 4 mg ondansetron or 0.9% normal saline 10 min before initiation of SAB. Hemodynamic parameters were studied from the time of administration of the study drug upto the time of delivery of baby. Results: Both the groups were comparable to each other with respect to baseline hemodynamic parameters. SAB-induced fall in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) was significantly less in the ondansetron group when compared with placebo from the time of initiation of SAB upto 12 min of surgery time (P < 0.05). However, the difference in heart rate between both groups was not statistically significant. The total use of vasopressors was significantly low in ondansetron group when compared with placebo (P < 0.05). Better neonatal outcomes were observed in the ondansetron group. Conclusion: Intravenous ondansetron premedication can successfully attenuate SAB-induced fall in SBP, DBP, and MAP in parturients undergoing elective caesarean sections.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed58    
    Printed0    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    

Recommend this journal