Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Journal of Obstrectic Anaesthesia and Critical Care
Search articles
Home Print this page Email this page Small font size Default font size Increase font size Users Online: 74
ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 2  |  Page : 81-87

Prophylactic administration of two different bolus doses of phenylephrine for prevention of spinal-induced hypotension during cesarean section: A prospective double-blinded clinical study


Department of Anaesthesiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

Correspondence Address:
Dr. Seema Partani
14 Nakoda Complex Hiran Magri Sector 4, Udaipur - 313 001, Rajasthan
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joacc.JOACC_20_19

Rights and Permissions

Background: Hypotension following spinal anesthesia during cesarean delivery can cause adverse maternal and fetal effects. Phenylephrine has been found to be a potent vasopressor in preventing spinal-induced hypotension during cesarean section (CS) without fetal acidosis. Material and Methods: In this prospective double-blinded study, 120 parturients of ASA grade I and II posted for CS under spinal anesthesia were randomized into three groups of 40 each: group P0, group P75, and group P100. The primary objective was to study the influence of two different doses of phenylephrine on the incidence of spinal-induced hypotension during cesarean section. Corelation of postural variations in baseline hemodynamic data with observed degree of orthostatic hypotension to predict intraoperative hypotension, requirement of rescue vasopressors, and incidence of side effects and neonatal outcome were the secondary outcome measures. Statistical analysis was done with SPSS version 16 using student t test, ANOVA, and Chi-square test. Results: Incidence of hypotension was 70%, 25%, and 17.50% in P0, P75, and P100 groups (P < 0.001), respectively. Maximum change in systolic blood pressure paralleled the increasing doses of prophylactic phenylephrine which was highest in P100 group as compared to P75 and P0 groups. Incidence of bradycardia was higher in group P100 than groups P75 and P0. There were no other significant differences among the three groups. Conclusion: Prophylactic bolus dose of phenylephrine 75 mcg was found to be effective for the management of spinal-induced hypotension and should be preferred over 100 mcg which causes significant bradycardia and reactive hypertension.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed217    
    Printed17    
    Emailed0    
    PDF Downloaded57    
    Comments [Add]    

Recommend this journal