|Year : 2013 | Volume
| Issue : 1 | Page : 16-22
Epidural labor analgesia: A comparison of ropivacaine 0.125% versus 0.2% with fentanyl
Yogesh Kumar Chhetty1, Udita Naithani2, Sunanda Gupta3, Vikram Bedi2, Ila Agrawal4, Lalatendu Swain2
1 Department of Anesthesia, R.N.T. Medical College; Department of Anesthesiology and Critical Care, Maa Gayatri Hospital, Udaipur, Rajasthan, India
2 Department of Anesthesia, R.N.T. Medical College, Udaipur, Rajasthan, India
3 Department of Anesthesia, R.N.T. Medical College; Department of Anesthesiology and Critical Care, Geetanjali Medical College, Udaipur, Rajasthan, India
4 Department of Obstetrics and Gynecology, R.N.T. Medical College, Udaipur, Rajasthan, India
|Date of Web Publication||1-Jul-2013|
"aahna", 26, Navratna Complex, Near Mahalaxmi Apartments, Near Bedla Road, Udaipur 313001, Rajasthan
Source of Support: None, Conflict of Interest: None
Background: Minimum effective concentration of local anesthetics for providing optimal labor epidural analgesia and the strategies aiming to reduce their consumption are continuously being searched.
Objectives: The objective of this study was to evaluate the efficacy of 0.125% and 0.2% ropivacaine both mixed with fentanyl 2 mcg/ml for epidural labor analgesia.
Materials and Methods: A total of 80 parturients in active labor were randomly assigned to two groups of 40 each, to receive an epidural injection of 15 ml ropivacaine 0.125% with fentanyl (2 mcg/ml) in group R1 and 15 ml of ropivacaine 0.2% with fentanyl (2 mcg/ml) in group R2 as initial bolus dose. Same dose regimen was used as subsequent top-up dose on patients demand for pain relief. The duration and quality of analgesia, motor block, top-up doses required consumption of ropivacaine and fentanyl and feto-maternal outcome in both groups were compared.
Results: Effective labor analgesia with no motor blockade was observed in both groups with no failure rate. Onset of analgesia was significantly faster in group R2 (75% parturients in 0-5 min) as compared to group R1 (25% parturients in 0-5 min), P < 0.001. Duration of analgesia after initial bolus dose was also significantly longer in group R2 (132 ± 56.81 min) than in group R1 (72.25 ± 40.26 min), P < 0.001. Mean VAS scores were significantly less in group R2 than in group R1 at 5, 60, and 90 min, P < 0.01. Requirement of top-up doses was significantly less in group R2 (0.05 ± 0.22) as compared to group R1 (0.80 ± 0.65), P < 0.001. Consumption of ropivacaine was comparable in both the groups (33.75 ± 12.16 mg in group R1 and 31.50 ± 6.62 mg in group R2 P > 0.05), but consumption of fentanyl was significantly more in group R1 (54.00 ± 19.45) as compared to group R2 (31.50 ± 6.62), P < 0.001. There were no significant changes in hemodynamics, nor adverse effects related to neonatal or maternal outcomes in both groups.
Conclusion: We conclude that both the concentrations of ropivacaine (0.2% and 0.125%) with fentanyl are effective in producing epidural labor analgesia. However, 0.2% concentration was found superior in terms of faster onset, prolonged duration, lesser breakthrough pain requiring lesser top-ups, and hence a lesser consumption of opioids.
Keywords: Epidural labor analgesia, labor analgesia, ropivacaine 0.2% versus 0.125%, fentanyl
|How to cite this article:|
Chhetty YK, Naithani U, Gupta S, Bedi V, Agrawal I, Swain L. Epidural labor analgesia: A comparison of ropivacaine 0.125% versus 0.2% with fentanyl. J Obstet Anaesth Crit Care 2013;3:16-22
|How to cite this URL:|
Chhetty YK, Naithani U, Gupta S, Bedi V, Agrawal I, Swain L. Epidural labor analgesia: A comparison of ropivacaine 0.125% versus 0.2% with fentanyl. J Obstet Anaesth Crit Care [serial online] 2013 [cited 2019 Nov 14];3:16-22. Available from: http://www.joacc.com/text.asp?2013/3/1/16/114284
| Introduction|| |
The pains of labor result in a maternal stress response, which is neither beneficial for the fetus nor the mother.  Evidence is suggestive that labor disorders including maternal hypertension, dystocia, meconium staining, and fetal distress are stress related. , Hence, maternal pain relief not only benefits the parturient, but her neonate also.
Maternal and fetal effects of analgesia during labor remain central to discussions among patients, anesthesiologists, and an obstetrical caregivers , with the controversies , in obstetrical anesthesia including the effects of regional anesthesia on the progress and outcome of labor as well as effects on the neonate. ,
Of all the available methods of labor analgesia, epidural analgesia satisfies the basic requirements of labor analgesia by fulfilling the objective of decreasing the pains of labor without affecting other sensations such as a desire to push and to allow normal walking while preserving the tone of pelvic floor muscles as well as retaining the sensation of the baby's head in the vagina; thus, allowing labor to proceed unhindered.
Ropivacaine, an amide local anesthetic is less cardiotoxic in animals  as well as it may also be more selective for sensory fibers when compared to other local anesthetics, producing less motor block.  This allows for increased maternal ambulation and also allows for normal progression of labor, which translates into fewer instrumental deliveries and more vaginal deliveries  although this is controversial.  These factors suggest that ropivacaine may be superior to bupivacaine in obstetric analgesia.
Minimum local anesthetic concentration (MLAC) studies by up and down sequential allocation have found both 0.2% and 0.1% ropivacaine to be effective for labor analgesia.  OPRM A118G gene has been reported to be present in a higher number of Asians as compared to their Western counterparts, which pre-disposes the Asian populace to a higher degree of pain perception.  Studies are lacking from the Indian subcontinent, which highlight the efficacy of 0.2% versus 0.125% ropivacaine for labor analgesia, which prompted us to undertake this study.
The objective of this study was to evaluate 0.125% versus 0.2% ropivacaine, with 2 μg/ml of fentanyl in epidural labor analgesia, regarding their sensory and motor block characteristics as well as the fetomaternal outcomes.
| Materials and Methods|| |
After approval of the Institutional Ethical Committee, this prospective randomized double-blinded study was conducted at a teaching hospital in Rajasthan on 80 term parturients of American Society of Anesthesiologists (ASA) grade I and II having uncomplicated pregnancy in a vertex presentation.
Parturients in active labor, having contractions at least once every 5 min, not having any contraindication to epidural analgesia, and who requested epidural analgesia for pain relief were enrolled in this study. Exclusion criteria included hypersensitivity to study drugs, bleeding disorders, decreased platelet counts, sepsis, and a history of drug abuse; spinal column deformities and spine surgery.
Sample size and group allocation
Expecting ropivacaine (0.2% vs. 0.125%) + fentanyl 2 μg/ml to decrease visual analog scale (VAS) scores to <3 values, a power analysis resulted in a calculated sample size of a minimum of 28 subjects per group to obtain statistical significance assuming and α error of 0.05 and power of 0.9. The study was designed to provide 90% power to detect a decrease in success rate from 90% to 70% with a one-tailed test at 5% significance level. However, since a minimum of 30 subjects are required for a clinical study to be valid and to compensate for dropouts a sample size of 40 subjects per group was chosen.
Study patients (n = 80) were randomly assigned to one of two groups of 40 each, using a computer generated table of random number to receive epidural injection using either, 15 ml of ropivacaine 0.125% with 2 μg/ml fentanyl (group R1) or 15 ml of ropivacaine 0.2% with 2 μg/ml fentanyl (group R2).
For group R1, 15 ml of 0.125% ropivacaine was prepared by taking 2.5 ml of 0.75% isobaric ropivacaine (Ropin® ) (Neon Laboratories Ltd. 140, Damji Samji Industrial Complex, Mahakali Caves Road, Andheri East, Mumbai, Maharashtra 400093) and diluting it with 12.5 ml of 0.9% normal saline. For group R2, 15 ml of ropivacaine (0.2%) was taken directly from a 20 ml ampoule (Ropin® , Neon). 30 μg of fentanyl (Trofentyl® , Troikaa Laboratories Ltd.) were taken by using six parts from a tuberculin syringe graduated in markings to divide 1 ml (50 mcg/ml) into 10 parts and added to 15 ml of ropivacaine in both groups to achieve a final concentration of fentanyl (2 mcg/ml).
Double blindness of the study was ensured by involving, three different anesthesiologists for preparing the drugs, administering them and for recording the data.
Labor analgesia technique
After informed consent patients were subjected to a thorough pre-anesthetic evaluation. Before placement of the epidural catheter, VAS score was noted with VAS 0 = no pain and 10 = the worst imaginable pain along with baseline vitals.
After starting a 500 ml infusion of Ringers' lactate in an 18G peripheral intravenous canula, parturients in both groups were placed in the left lateral position. Following strict aseptic techniques, and infiltrating 2% lignocaine HCl into the intervertebral space, epidural space was identified at L 3-4 or L 4-5 space using a loss of resistance technique to normal saline with an 18G Tuohy needle and an 18-gauge multi-orifice catheter was threaded through the cephalad directed tip of the epidural needle to a depth of 5 cm into the epidural space. If there was no blood or cerebro spinal fluid (CSF) on aspiration from the epidural catheter, depending on the group allocated, a 3-ml test dose of the study medication was administered through the catheter. The presence of clinical signs of an intravascular injection were sought, for the following 2-3 min, by asking the patient whether she felt dizzy, had tinnitus, or a metallic taste in her mouth. If there were no signs of an intravascular injection, the catheter was secured and the woman was placed in the supine position with left uterine displacement. Five minutes after the test dose, if there were no clinical signs of subarachnoid injection (as evidenced by the patient's ability to move her legs and the absence of hypotension), an additional 12 ml of the study solution was administered. This dose was defined as first initial bolus dose and time was noted. On intravascular placement of the catheter, it was removed and resisted at another interspace while all patients with intradural placement of catheter were removed from the study. The adequacy of analgesia was assessed 5 min after the first initial bolus dose of study drug had been administered. Analgesia was considered adequate if pain score was <3. Onset of analgesia was defined as from time of first bolus dose to time of achieving VAS <3. If analgesia was not adequate 15 min after the first initial dose, an additional 15 ml of study medication (second initial dose) was administered, and analgesia reassessed in the same manner. If pain relief was inadequate at the peak of a contraction, 15 min after the second initial dose of ropivacaine; the epidural anesthetic was classified as ropivacaine failure, and patient withdrawn from the study. Presence of motor block in the lower extremities was assessed using a Breen modified Bromage scale (BMBS: Grade 1 as complete motor block to Grade 6 as no motor block). VAS and BMBS was assessed every 15 min. All parturients were given a trial walk to assess their ability to ambulate. An additional dose of ropivacaine 15 ml was given as a top-up dose on patient request, with a minimum gap of 15 min between two subsequent top-up doses. Epidural analgesia was continued through the second stage of labor.
At any point of time during the study period hypotension was defined as systolic blood pressure of <90 mmHg and was treated with bolus of 6 mg ephedrine HCl. Bradycardia was defined as heart rate <60 bpm and was treated with bolus doses of 0.4 mg atropine sulfate.
Demographic data (age, weight, height), obstetric data (parity, dilatation of the cervix [0-10 cm], station of the vertex of the presenting part [−3 to +3], effacement of the cervix (%), membrane status) were noted prior to the initiation of labor analgesia.
Pain score (VAS), sensory and motor block characteristics and vital parameters (pulse, mean arterial pressure, respiratory rate) were recorded at 0 (before epidural), 5, 15 min and then every 15 min till 1 h and then every 30 min until the delivery. Sensory block height was assessed by loss of sensation to pin prick (blunt head of a pin). Onset of analgesia was defined as duration from injection of first initial epidural bolus dose to attainment of VAS <3 and duration of analgesia of initial bolus dose was defined as time of administration of study drug until the time of demand of top-up for the first time.
Motor block assessment was carried out by BMBS, ,,,,, Romberg's sign, straight leg raising test, rectus abdominalis muscle test, and trial walk.
The time taken by the parturient to request for subsequent top-up dose was recorded. Labor was managed according to our obstetric department's protocols and mode of delivery (normal/instrumental delivery/caesarean delivery) was noted. Injection delivery interval was defined as the time from administration of first initial epidural dose until the delivery. Fetal heart rate was monitored throughout the study by using a cardiotocograph, and any evidence of fetal heart rate decelerations was recorded. Neonatal assessment was performed by assessing the Apgar score at 1 and 5 min.
Quality of maternal expulsive efforts was assessed by an obstetrician as Grade 0 - Failure, 1 -Incomplete, 2 - Good, 3 - Excellent. Quality of analgesia was assessed by an esthesiologist as Grade 0 - Failure, 1 - Incomplete, 2 - Good, 3 - Excellent, 4 - Not possible to evaluate (NPE) if delivered by cesarean section. Side-effects including nausea, vomiting, hypotension, hypersensitive reaction, shivering, fever, drowsiness, pruritus, respiratory depression, retention of urine, and weakness in limbs were noted.
For categorical variables (presented as number [proportions]), the proportions of variances in the two groups were compared using the Chi-squared test with calculation of the χ2 statistic value and P value. For quantitative variables (data presented as mean ± standard deviation [SD] measurements), the groups were compared using Student's t-test for independent samples. For all statistical analyses, the level of significance was P < 0.05 and the software used was Microsoft Excel 2007 and Statistical Package for the Social Sciences (SPSS) (IBM Business analytics software) version 20.0.0.
| Results|| |
Demographic data, obstetric data, and injection delivery interval were comparable in both groups, P > 0.05 [Table 1]. Before initiation of analgesia mean VAS score was 9.80 ± 0.61 in group R1 and 9.90 ± 0.50 in group R2 (P > 0.05). Both the concentrations of ropivacaine (0.125% in group R1 and 0.2% in group R2) produced effective analgesia (defined by VAS <3) after single initial bolus dose in parturients of both the groups, stating no failure rate.
After epidural injection majority of parturients (75%) achieved VAS <3 significantly earlier in group R2 (0-5 min), than in group R1 (5-15 min), signifying onset of analgesia to be significantly faster in group R2 as compared to group R1, P < 0.001. After 5 min of epidural bolus injection, VAS score was significantly less in group R2 (1.63 ± 2.89) than in group R1 (5.00 ± 2.89) P < 0.001. All the parturients in both the groups attained a sensory blockade level of T 10 and none of the patients in both the groups showed a sensory block higher than T 10 . Duration of analgesia of initial bolus dose, defined as the time until parturient requests for additional analgesia (first top-up), was calculated for all 40 patients in each group and was found to be significantly more in group R2 (132 ± 56.81 min) than in group R1 (72.25 ± 40.26 min) (P < 0.001). In group R2 only 2 (5%) patients required a single top-up dose and 38 (95%) patients had adequate analgesia until the delivery after initial bolus dose, whereas in group R1 only 13 (32.5%) parturients could achieve effective analgesia until the delivery after initial bolus dose, 22 (55%) required a single top-up dose and 5 (12.5) required two top-ups (P < 0.001). Overall significantly higher number of parturients in group R1 (n = 27, 67.5%) required one or more top-up doses (P < 0.001). first top-up dose was required significantly earlier in group R1 (58.15 ± 22.65 min) than in group R2 (131.30 ± 57.11 min), P < 0.001. Mean number of top-up doses for each patient was significantly higher in group R1 (0.80 ± 0.65) than in group R2 (0.05 ± 0.22), P < 0.001. Total dose of ropivacaine consumed in both groups was comparable (P > 0.05), but total dose of fentanyl was significantly higher in group R1 (54.00 ± 19.45 mcg) than in group R2 (31.50 ± 6.62 mcg) P < 0.001 [Table 2].
VAS scores were significantly lower in group R2 than in group R1 at 5 min, 60 min and 90 min of the study period, P < 0.001 [Figure 1]. Motor block characteristics in both groups were comparable. All parturients had negative Romberg's sign and straight leg raising test with a positive trial walk and a BMBS of 6 significantly no motor blockade at all-time intervals of the study.
Haemodynamic status of parturients in both groups was comparable. None of the patients in any group required either ephedrine or atropine [Table 3].
Spontaneous vaginal delivery occurred in all (100%) parturients in group R1 and 95% (n = 38) in group R2. 1 (2.5%) parturient each had forceps and cesarean delivery in group R2, P > 0.05.
Obstetrician's graded maternal expulsive efforts as excellent in most of the parturients in both groups (P > 0.05). Parturients and anesthesiologists graded acceptance rate as either excellent or "good" in both groups. However, significantly higher number of cases (97.5%) reported acceptance rate as excellent in group R2, by both parturients and anesthesiologists (P < 0.001) [Table 4].
|Table 4: Maternal expulsive efforts assessed by obstetrician and quality of analgesia (as assessed by parturient and anesthesiologist)|
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Neonatal outcome was favorable in both the groups (Apgar scores >7 at 1 and 5 min) with no side-effects.
| Discussion|| |
The last few years have been marked by the arrival of new local anesthetics; ropivacaine and levobupivacaine, with reduced systemic toxicity and a better preservation of motor function.  Toxicity is not an issue when low concentrations of local anesthetics are used as is the case in modern neuraxial labor analgesia.  It seems evident that the adequate dilution of local anesthetics and the strategies aiming to reduce their consumption are more important than the choice of the local anesthetic by itself when the goal is to provide optimal neuraxial labor analgesia.
There are controversial data regarding minimum effective concentration of ropivacaine for initiation of epidural labor analgesia. Using up and down sequential allocation MLAC of ropivacaine for epidural labor analgesia was reported to be 0.111% w/v (95% confidence interval [CI], 0.100-0.112).  In another study MLAC of ropivacaine alone was 0.13% (95% CI, 0.12-0.13) compared to 0.09% (95% CI, 0.08-0.1) with sufentanil, P < 0.01.  On the other hand, many authors  found that ropivacaine 0.2% offers adequate analgesia more often than either 0.15% or 0.1% and the resultant motor blocks and hemodynamic effects are minimal. Addition of fentanyl 2 mcg/ml to 0.1% ropivacaine improved analgesia to a quality similar to 0.2% ropivacaine. 
In the present study, epidural labor analgesia with ropivacaine 0.125% or 0.2% both combined with fentanyl (2 mcg/ml) produced adequate labor analgesia in all the 80 parturients in both groups showing a 100% success rate of both concentrations.
However, we observed that the onset of analgesia was significantly faster when labor analgesia was initiated with 0.2% ropivacaine as reported earlier that a decrease in time for onset occurs with increasing concentrations of epidural bupivacaine. , In contrast, no difference in the onset of analgesia with increasing concentration of ropivacaine had also been reported.  Duration of analgesia of initial bolus dose was also significantly more with 0.2% ropivacaine in our study as observed by others.  Addition of adjuvant opioids leads to further increase in duration of analgesia.  Time of first top-up was also significantly more in 0.2% group, which is in concordance to other studies. , Requirement of top-up doses was also significantly less frequent in 0.2% group, but total dose of ropivacaine was comparable in two groups (31.75 mg in group R2 and 33.75 mg in group R1) because repeated top-ups of 0.125% ropivacaine resulted in same total dose of ropivacaine. Nevertheless repeated top-up doses had 2 mcg/ml fentanyl and led to consumption of significantly higher amount of fentanyl in group R1 (54 mcg in group R1 vs. 31.50 mcg in group R2). The recent trend in practitioners of labor analgesia is to use the least possible concentration of local anesthetic and adjuvant for the purpose of attaining analgesia. The main undesirable side-effects with ropivacaine analgesia are hypotension, bradycardia, nausea, paresthesia, and urinary retention, which are considered mild and transient. However, the side-effects observed with opioids are multivariate (nausea, pruritus, respiratory depression, lower Apgar scores in the neonate). All of these undesirable effects warrant a decrease in the dosage of epidural opioids that are used for analgesia in the laboring patient. The amount of ropivacaine and fentanyl that were required to attain analgesia in our study were comparatively high. This could be attributed to the differences in the techniques of administering analgesia : i0 ntermittent boluses versus infusion by patient controlled epidural analgesia (PCEA). Studies have demonstrated that PCEA labor analgesia consumes significantly lesser amount of the local anesthetic opioid mixture. , Interestingly, Tan et al. (2009),  in their study concluded that the A118G single nucleotide polymorphism of the human mu opioid receptor (OPRM) gene influences one's requirement of additional analgesia.
In the present study, no motor block was observed in both groups, which is in concordance to others. ,, However, higher incidence of motor block in previous studies could be attributed to higher concentrations of ropivacaine (0.25%, 0.275%,  0.5%  ). In a Cochrane systematic review of epidural versus no analgesic in labor that included 38 studies involving 9658 women; 13 of the studies reported hypotension as an adverse effect.  We also observed slight fall in the MAP and heart rate, but none of the patients had episodes of hypotension and bradycardia requiring treatment as was also noted earlier , that changes in maternal pulse rate (PR) and blood pressure are not related to change in the dose of local anesthetic.
Injection delivery interval was comparable in both groups, but it was shorter as compared to others. ,, The reason for this difference is probably because other studies included only nulliparous parturients, whereas we studied both nullipara and multipara parturients and a significant correlation between parity and duration of labor has been found in earlier studies. 
In our study, maternal expulsive effort, instrumental delivery, and neonatal status were comparable in both groups as observed by others. ,, Authors of the Cochrane systematic review (2011)  opined that epidural analgesia appeared to be effective in reducing pain during labor. However, women who used this form of pain relief were at increased risk of having an instrumental delivery. Epidural analgesia had no statistically significant impact on the risk of cesarean section, maternal satisfaction with pain relief and long-term backache and did not appear to have an immediate effect on neonatal status as determined by Apgar scores. However, they also stated that further research would be helpful to evaluate rare but potentially severe adverse effects of epidural analgesia on women in labor and long-term neonatal outcomes. Our study was not designed with the objective of assessing the mode of delivery of the parturients participating in the study. Hence, appropriately powered and designed studies may help in further researching this aspect of labor analgesia.
No parturient had hypotension, hypersensitivity reaction, pruritus, nausea, urinary retention, vomiting, respiratory depression, weakness in the limbs or shivering, though cases of pruritus,  hypotension,  have been reported with epidural labor analgesia. Both concentrations produced maternal expulsive efforts, parturient and anesthesiologist acceptance grades in excellent or good range similar to Beilin (92% satisfaction)  and Lee  who reported a satisfaction grade of 8 on a scale of 10 for all concentrations. However, in our study parturient and anesthesiologist acceptance was significantly superior in R2 group, which could be attributable to less breakthrough pain that caused significantly less number of top-up requirement and VAS also remained significantly low at various time intervals.
The limitations of this study could be a requirement of a larger sample size which would give a wider perspective on maternal and neonatal side-effects. Similarly, a comparison of intermittent boluses versus a continuous infusion technique would give a better estimation of local anesthetic and opioid consumption in both groups.
| Conclusion|| |
In spite of the above limitations, we have arrived at the conclusion that both the concentrations are effective in producing labor analgesia. Group R2 (0.2% ropivacaine) parturients; however, had a faster onset and significantly longer duration of analgesia with a single dose and required lesser top-ups, resulting in a significantly reduced consumption of opioids. Hence, our study favors, the use of 15 ml of 0.2% ropivacaine with 2 mcg/ml fentanyl over 0.125% ropivacaine for labor analgesia.
It would be further interesting to evaluate the effect of varying the dose of administered drugs according to the stages and intensity of labor, which could further regulate the requirement of drugs and provide more effective analgesia.
| References|| |
|1.||Shnider SM, Abboud TK, Artal R, Henriksen EH, Stefani SJ, Levinson G. Maternal catecholamines decrease during labor after lumbar epidural anesthesia. Am J Obstet Gynecol 1983;147:13-5. |
|2.||Pearson JF, Davies P. The effect of continuous lumbar epidural analgesia upon fetal acid-base status during the first stage of labour. J Obstet Gynaecol Br Commonw 1974;81:971-4. |
|3.||Eltzschig HK, Lieberman ES, Camann WR. Regional anesthesia and analgesia for labor and delivery. N Engl J Med 2003;348:319-32. |
|4.||Kannan S, Jamison RN, Datta S. Maternal satisfaction and pain control in women electing natural childbirth. Reg Anesth Pain Med 2001;26:468-72. |
|5.||Beilin Y, Leibowitz AB, Bernstein HH, Abramovitz SE. Controversies of labor epidural analgesia. Anesth Analg 1999;89:969-78. |
|6.||Writer WD, Stienstra R, Eddleston JM, Gatt SP, Griffin R, Gutsche BB, et al. Neonatal outcome and mode of delivery after epidural analgesia for labour with ropivacaine and bupivacaine: A prospective meta-analysis. Br J Anaesth 1998;81:713-7. |
|7.||Nancarrow C, Rutten AJ, Runciman WB, Mather LE, Carapetis RJ, McLean CF, et al. Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesth Analg 1989;69:276-83. |
|8.||Zaric D, Nydahl PA, Philipson L, Samuelsson L, Heierson A, Axelsson K. The effect of continuous lumbar epidural infusion of ropivacaine (0.1%, 0.2%, and 0.3%) and 0.25% bupivacaine on sensory and motor block in volunteers: A double-blind study. Reg Anesth 1996;21:14-25. |
|9.||Comparative Obstetric Mobile Epidural Trial (COMET) Study Group UK. Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: A randomised controlled trial. Lancet 2001;358:19-23. |
|10.||Nageotte MP, Larson D, Rumney PJ, Sidhu M, Hollenbach K. Epidural analgesia compared with combined spinal-epidural analgesia during labor in nulliparous women. N Engl J Med 1997;337:1715-9. |
|11.||Aveline C, El Metaoua S, Masmoudi A, Boelle PY, Bonnet F. The effect of clonidine on the minimum local analgesic concentration of epidural ropivacaine during labor. Anesth Analg 2002;95:735-40, table of contents. |
|12.||Tan EC, Lim Y, Teo YY, Goh R, Law HY, Sia AT. Ethnic differences in pain perception and patient-controlled analgesia usage for postoperative pain. J Pain 2008;9:849-55. |
|13.||Dewandre PY. The right drug and dose for neuraxial labour analgesia. Acta Anaesthesiol Belg 2006;57:395-9. |
|14.||Polley LS, Columb MO, Naughton NN, Wagner DS, van de Ven CJ. Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: Implications for therapeutic indexes. Anesthesiology 1999;90:944-50. |
|15.||Palm S, Gertzen W, Ledowski T, Gleim M, Wulf H. Minimum local analgesic dose of plain ropivacaine vs. ropivacaine combined with sufentanil during epidural analgesia for labour. Anaesthesia 2001;56:526-9. |
|16.||Dresner M, Freeman J, Calow C, Quinn A, Bamber J. Ropivacaine 0.2% versus bupivacaine 0.1% with fentanyl: A double blind comparison for analgesia during labour. Br J Anaesth 2000;85:826-9. |
|17.||Lee BB, Ngan Kee WD, Lau WM, Wong AS. Epidural infusions for labor analgesia: A comparison of 0.2% ropivacaine, 0.1% ropivacaine, and 0.1% ropivacaine with fentanyl. Reg Anesth Pain Med 2002;27:31-6. |
|18.||Handley G, Perkins G. The addition of pethidine to epidural bupivacaine in labour - Effect of changing bupivacaine strength. Anaesth Intensive Care 1992;20:151-5. |
|19.||Duggan J, Bowler GM, McClure JH, Wildsmith JA. Extradural block with bupivacaine: Influence of dose, volume, concentration and patient characteristics. Br J Anaesth 1988;61:324-31. |
|20.||Lee BB, Ngan Kee WD, Wong EL, Liu JY. Dose-response study of epidural ropivacaine for labor analgesia. Anesthesiology 2001;94:767-72. |
|21.||Beilin Y, Galea M, Zahn J, Bodian CA. Epidural ropivacaine for the initiation of labor epidural analgesia: A dose finding study. Anesth Analg 1999;88:1340-5. |
|22.||Bang EC, Shin JH, Lee HS, Kang YI, Cho KS, Kim SY. The onset and duration of 0.2% ropivacaine with a varying dose of fentanyl in epidural labor analgesia. Anesth Pain Med 2010;5:249-54. |
|23.||Ngan Kee WD, Ng FF, Khaw KS, Lee A, Gin T. Determination and comparison of graded dose-response curves for epidural bupivacaine and ropivacaine for analgesia in laboring nulliparous women. Anesthesiology 2010;113:445-53. |
|24.||Boutros A, Blary S, Bronchard R, Bonnet F. Comparison of intermittent epidural bolus, continuous epidural infusion and patient controlled-epidural analgesia during labor. Int J Obstet Anesth 1999;8:236-41. |
|25.||Collis RE, Plaat FS, Morgan BM. Comparison of midwife top-ups, continuous infusion and patient-controlled epidural analgesia for maintaining mobility after a low-dose combined spinal-epidural. Br J Anaesth 1999;82:233-6. |
|26.||Debon R, Allaouchiche B, Duflo F, Boselli E, Chassard D. The analgesic effect of sufentanil combined with ropivacaine 0.2% for labor analgesia: A comparison of three sufentanil doses. Anesth Analg 2001;92:180-3. |
|27.||Eddleston JM, Holland JJ, Griffin RP, Corbett A, Horsman EL, Reynolds F. A double-blind comparison of 0.25% ropivacaine and 0.25% bupivacaine for extradural analgesia in labour. Br J Anaesth 1996;76:66-71. |
|28.||McCrae AF, Jozwiak H, McClure JH. Comparison of ropivacaine and bupivacaine in extradural analgesia for the relief of pain in labour. Br J Anaesth 1995;74:261-5. |
|29.||Anim-Somuah M, Smyth RM, Jones L. Epidural versus non-epidural or no analgesia in labour. Cochrane Database Syst Rev 2011:CD000331. |
|30.||Bernard JM, Le Roux D, Frouin J. Ropivacaine and fentanyl concentrations in patient-controlled epidural analgesia during labor: A volume-range study. Anesth Analg 2003;97:1800-7. |
|31.||Lim Y, Ocampo CE, Supandji M, Teoh WH, Sia AT. A randomized controlled trial of three patient-controlled epidural analgesia regimens for labor. Anesth Analg 2008;107:1968-72. |
|32.||Ijaiya MA, Adesina KT, Raji HO, Aboyeji AP, Olatinwo AO, Adeniran AS, et al. Duration of labor with spontaneous onset at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. Ann Afr Med 2011;10:115-9. |
|33.|| Lee HL, Lo LM, Chou CC, Chiang TY, Chuah EC. Timing of initiating epidural analgesia and mode of delivery in nulliparas: A retrospective experience using ropivacaine. Chang Gung Med J 2008;31:395-401. |
[Table 1], [Table 2], [Table 3], [Table 4]